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They were initially defined as secretory GPX, but later studies have shown that both enzymes are localized to the endoplasmic reticulum and are necessary enzymes involved in the oxidative folding of endoplasmic reticulum proteins (Figure 8)

The chaperone functionality of sHsps is attributed to the ACD, which consists of two -sheets flanked by -helices

Acosta is also co-founder of Phenomix Sciences, a company selling genetic testing through some doctors' offices